Faculty
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Rajesh Nair, Chair
Guy’s and St. Thomas’ NHS Foundation Trust
London, UK
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Maria Carmen Mir Maresma
Instituto Valenciano de Oncología
Valencia, Spain
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Mario W. Kramer
Universitätsklinikum Schleswig-Holstein
Lübeck, Germany
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Overview
Immune checkpoint inhibitors play a key role in medical management of select patients with urologic cancers. Using interactive case discussions, this session will focus on the rationale for targeting the immune checkpoint pathway in bladder and renal cancers; the role of biomarkers such as programmed death-ligand 1 (PD-L1) and tumor mutation burden (TMB) to guide the selection of appropriate first- and subsequent-line therapy; the use of immune-specific response criteria to monitor treatment response; and options for managing immune-related adverse events during treatment.
Learning objectives
- Evaluate the rationale for targeting immune checkpoint molecules in bladder and renal cancers
- Apply the latest clinical evidence to the selection and sequencing of immuno-oncology (IO) therapies in patients with bladder and renal cancers
- Select appropriate strategies to assess treatment response and mitigate adverse events during IO therapy
Agenda
Sunday, 17 March 2019 | Green Room 1
17:45 – 17:50
Welcome and introduction
R. Nair, London (UK)
17:50 – 18:15
Checkpoint inhibitors in urologic cancers: where are we and where are we going?
M.C. Mir Maresma, Valencia (ES)
M.W. Kramer, Lübeck (DE)
18:15 – 18:40
Case 1: patient with advanced renal cancer
M.C. Mir Maresma, Valencia (ES)
18:40 – 19:05
Case 2: patient with newly diagnosed bladder cancer
M.W. Kramer, Lübeck (DE)
19:05 – 19:15
Q & A and closing remarks
R. Nair, London (UK)
CME information
Siyemi Learning is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Siyemi Learning designates this activity for 1.5 AMA PRA Category 1 credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

Disclosure statement
Siyemi Learning, as an organisation accredited by the ACCME, requires everyone involved in this CME activity to disclose all relevant financial relationships. This is defined as a financial relationship (including that of a spouse or partner), in any amount, occurring in the past 12 months, that could lead to potential bias.
Mario W. Kramer has served as an advisor for: BMS, Pfizer, Pierre Fabre, MSD and Roche.
Rajesh Nair and M. Carmen Mir Maresma have no relevant financial relationships to disclose.
Staff at Siyemi Learning have no relevant financial relationships to disclose.
Commercial support
This educational activity is supported by an independent education grant from MSD.